Journal of SAFOMS

Register      Login

VOLUME 6 , ISSUE 2 ( July-December, 2018 ) > List of Articles

Original Article

Histopathological Evaluation of Endometrium in Perimenopausal Women with Fibroids

Peeyusha W Rajani, Annie Rajaratnam

Keywords : Abnormal uterine bleeding, Endometrial thickness, Leiomyoma, Perimenopausal women

Citation Information : Rajani PW, Rajaratnam A. Histopathological Evaluation of Endometrium in Perimenopausal Women with Fibroids. J South Asian Feder Menopause Soc 2018; 6 (2):88-90.

DOI: 10.5005/jp-journals-10032-1146

License: CC BY-NC 4.0

Published Online: 01-12-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: Steroid hormones causes functional and structural changes in endometrium throughout each menstrual cycle. Uterine leiomyomas being dependent on steroid growth hormones for their growth and maintenance account for more than 75% of the benign tumors in females of childbearing age group. Formation of fibroids hence is a common response to this pathologic state. The aim of our study was to correlate endometrial histopathology in perimenopausal women with fibroids presenting as abnormal uterine bleeding (AUB-L). Materials and methods: Fifty women of perimenopausal age, presenting with abnormal uterine bleeding, wherein the uterus revealed leiomyoma were studied. Endometrial thickness was measured using vaginal or pelvic ultrasonography. Endometrial biopsy was taken, and the samples were sent for histopathological examination. Ten asymptomatic normal women of similar age group were taken as controls. Results: Uterine size was nonsignificantly increased in a peri-menopausal woman with fibroid. The average size of fibroid was 3.10 to 3.24 cm. Mean endometrial thickness with fibroid was significantly higher as compared to normal females of similar age group. Conclusion: Presence of fibroid was associated with an increase in endometrial thickness in perimenopausal women, along with a small change in uterine size.


PDF Share
  1. Astrup K, Olivarius NF. Frequency of spontaneously occurring postmenopausal bleeding in the general population. Acta Obstet Gynecol Scand 2004;83:203-207.
  2. Guruwadayarhalli B, Jones SE, et al. Hysteroscopy in the diagnosis of postmenopausal bleeding. Menopause Int 2007;13:132-134.
  3. Dockery P. The fine structure of the mature human endometrium. In: Glasser SR, Aplin JD, Guidice LC, Tabibzadeh S, editors. The Endometrium. London: Informa Health Care 2002;21-36.
  4. Crum CP. Body of uterus and endometrium. In: Kumar V, Abbas AK, Fausto N, editors. Robbins and Cotran Pathologic Basis of Disease. 7th edn. Philadelphia: Saunders, 2004;1089-1090.
  5. Gull B, Karlson B, et al. Factors associated with endometrial thickness and uterine size in random samples of postmenopausal women. Am J Obstet Gynecol 2001;185(2):386-391
  6. Vollenhoven BJ, Lawrence AS, et al. Uterine fibroids: A clinical review. Br J Obstet Gynaecol 1990;97:285-298.
  7. Uterus. In: Standring S, editor. Gray's Anatomy, The Anatomical Basis of Clinical Practice. 39th edn. Spain: Elsevier, 2005: 1331-1339.
  8. Goldstein SR, Zeltser I, et al. Ultrasonography-based triage for perimenopausal patients with abnormal uterine bleeding. Am J Obstet Gynecol 1997;177(1):102-108.
  9. Sulaiman S, Khaund A, et al. Uterine fibroid do size and location determine menstrual blood loss? Eur J Obstet Gynecol Reprod Bio 2004;115(1):85-89.
  10. DeCastro A. Assessment of uterine shape and size using Kurz's cavimeter. Adv contracept 1988;4:115-123.
  11. Somigliana E, Vercellini P, et al. Fibroids and female reproduction: a critical analysis of the evidence. Hum Reprod Update 2007;13(5):465-476.
  12. Esmaelzadeh S, Rezaei N, et al. Normal uterine size in women of reproductive age in northern Islamic Republic of Iran. East Mediterr Health J 2004;10(3):437-441.
  13. Porozhanova V, Porozhanova K. Uterine fibromas and infertility. Akush Ginekol (Sofiia) 2004;43(6):33-38.
  14. Dreisler E, Sorensen SS, et al. Value of endometrialthickness measurement for diagnosing focal intrauterine pathology in women without abnormal uterine bleeding. Ultrasound Obstet Gynecol 2009;33(3):344-348.
  15. Getpook C, Wattanakumtornkul S. Endometrial thickness screening in premenopausal women with abnormal uterine bleeding. J Obstet Gynaecol Res 2006;32(6):588-592.
  16. Ozdemir S, Celik C, et al. Evaluation of endometrial thickness with transvaginal ultrasonography and histopathology in premenopausal women with abnormal vaginal bleeding. Arch Gynecol Obstet 2010;282(4):395-399.
  17. Chhabra S, Ohri N. Leiomyoma of uterus–A clinical study. J Obstet Gynaecol Indi. 1993;33:438-439.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.