Background: Hysterectomy is the surgical removal of the uterus. It may involve removal of the ovaries, fallopian tube, cervix, and the surrounding structures. The objective of the study was to assess the level of knowledge regarding hysterectomy among women attending obstetrics and gynecological area in a tertiary care hospital in Kochi. Materials and methods: A descriptive design was used to select 40 participants from obstetrics and gynecology area in a tertiary care hospital in Kochi. These subjects were to undergo hysterectomy. The subjects was selected using nonprobability convenience sampling technique. A semi-structured knowledge questionnaire was designed and administered. Results: Of the 40 women who participated in the study, 42.5% woman had poor knowledge, 57.5% had average knowledge, and none of them had good knowledge about hysterectomy. The mean knowledge score obtained by the women was 10.1500 with a standard deviation of 4.04177. About the various aspects of hysterectomy knowledge, majority were having inadequate knowledge regarding exercise (85%), diet (80%), management (75%), investigations (82.5%), and complications (56.25%). However, 52.5% of subjects showed adequate knowledge regarding hysterectomy. Conclusion: The majority of women attending gynecological area were not sufficiently knowledgeable about hysterectomy and its management. This underlines the need for the involvement of health personnel in hysterectomy and care to provide information for women undergoing hysterectomy.