Introduction: Pelvic inflammatory disease (PID) refers to an infectious and inflammatory disorder of the female upper genital tract. It is common among young sexually active individuals and is a major health problem both in developed and developing countries. It is usually a polymicrobial infection; however, Chlamydia trachomatis is the commonest causative agent transmitted sexually. Pelvic inflammatory disease is diagnosed by history and clinical examination. The treatment is initially empiric. Only antibiotics are good in treatment for PID and “antibiotics with prebiotics” are a new promising treatment mode for the same. This comparative study aimed to measure efficiency and compliance of only antibiotics vs antibiotics with prebiotics in the treatment of mild, uncomplicated acute PID. Setting: Multispecialty Hospital Pune. Duration: 6 months. Materials and methods: A descriptive cross-sectional study was conducted in randomly selected 28 consecutive outpatients with mild uncomplicated acute PID. Comparative outcome of antibiotics and antibiotics with prebiotics in correlation with the reduction of amount, consistency, and malodor of vaginal discharge along with the reduction in fornical tenderness, compliance, and frequency of adverse drug reactions was done. Results: Among 28 cases, 14 (50%) were treated with oral antibiotics and 14 (50%) with oral antibiotics with prebiotics. Comparative analysis on the reduction of amount, consistency, malodor of vaginal discharge, and reduction of fornical tenderness was significant, showing antibiotics with prebiotics more effective than antibiotics. Besides, compliance was better and there were fewer adverse drug reactions with antibiotics with prebiotics. Conclusion: Antibiotics with prebiotics have better efficiency and compliance over only antibiotics in the treatment of mild, uncomplicated, acute PID.
Vaginal discharge: how to pin point cause? Postgrad Med 1995;98(3):87–90. DOI: 10.1080/00325481.1995.11946044.
Global control of sexually transmitted infections. Lancet 2006;368(9551):2001–2016. DOI: 10.1016/S0140-6736(06)69482-8.
Programs to reduce pelvic inflammatory disease—the swedish experience. Lancet 1998;351(Suppl 3):25–28. DOI: 10.1016/S0140-6736(98)90008-3.
Female genital chlamydia trachomatis infection: where are we heading? Arch Gynecol Obstet 2012;285(5):1271–1285. DOI: 10.1007/s00404-012-2240-7.
Timing of progression from chlamydia trachomatis infection to pelvic inflammatory disease: a mathematical modeling study. BMC Infect Dis 2012;12:187. DOI: 10.1186/1471-2334-12-187.
PID, HIV and African-Americans. Emerg Infect Dis 2001;7:927–932. DOI: 10.3201/eid0706.010603.
Predictors of infection with PID: prospective study of low income African-American adolescent females. Sex Trans Dis 2002;78:360–364. DOI: 10.1136/sti.78.5.360.
Sexually transmitted diseases in gynecological practice. J Obstet Gynecol India 1998;38:3–9.
Risk factors in PID: a case control study among college students. Epidemiology 1996;7:182–187. DOI: 10.1097/00001648-199603000-00013.
Sexual transmission of PID. Obstet Gynecol 1987;69:883–886.
Pelvic inflammatory disease in adolescents. Adolesc Med Clin 2004;15(2):273–285. DOI: 10.1016/j.admecli.2004.02.005.
Gynecologic infections. Emerg med Clin North Am 2003;21(3):631–648. DOI: 10.1016/S0733-8627(03)00039-7.
MR imaging in pelvic inflammatory disease: comparison with laparoscopy and US. Radiology 1999;210(1):209–216. DOI: 10.1148/radiology.210.1.r99ja04209.
Laboratory confirmed gonorrhea and/or chlamydia rates in clinically diagnosed pelvic inflammatory disease and cervicitis. Am J Emerg Med 2012;30(7):1114–1117. DOI: 10.1016/j.ajem.2011.07.014.
Assessment of best single sample for finding chlamydia in women with and without symptoms: A diagnostic test study. BMJ 2012;345:e8013. DOI: 10.1136/bmj.e8013.
Pelvic inflammatory disease evaluation and clinical health (PEACH) study investigators. Effectiveness of inpatient and outpatient treatment strategies for women with pelvic inflammatory disease: a randomized trial. Am J Obstet Gynecol 2001;186(3):929–937. DOI: 10.1067/mob.2002.121625.