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VOLUME 5 , ISSUE 1 ( January-June, 2017 ) > List of Articles

ORIGINAL ARTICLE

Review of Cervical Carcinoma Screening Program in Tamil Nadu – Current Trend and Recommendations from a Histopathologist’s Viewpoint

Shifa S Ibrahim, Kamaleshwari Kesavaraj, Muthumani Arun, SA Mohamed Ameen, Raasi Sankar

Citation Information : Ibrahim SS, Kesavaraj K, Arun M, Ameen SM, Sankar R. Review of Cervical Carcinoma Screening Program in Tamil Nadu – Current Trend and Recommendations from a Histopathologist’s Viewpoint. J South Asian Feder Menopause Soc 2017; 5 (1):1-7.

DOI: 10.5005/jp-journals-10032-1095

Published Online: 01-07-2016

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

Objectives

Cervical carcinoma, the commonest carcinoma affecting Indian females, is caused by human papilloma virus (HPV) infection. Primordial prevention and primary prevention with HPV vaccine and cancer screening respectively, can go a long way in preventing this carcinoma. The health system project in Tamil Nadu has done a commendable job in reducing the disease burden by introducing screening programs for cervical carcinoma at the grassroots level, way back in 2005. This study was done to evaluate the cervical biopsy specimens received as a part of this program to compute its incidence, compare the incidence among various districts, and suggest future directions based on our observations.

Materials and methods

From visual inspection with acetic acid/visual inspection with Lugol’s iodine positive cervical biopsy specimens, 506 were chosen randomly from various districts. Based on histopathological examination, incidence of individual lesions and district-wise incidence were calculated. Predictive factors that determine the progression of these lesions were analyzed based on the literature.

Results

Out of the 506 cervical biopsy specimens, 34 were unsatisfactory. The incidence of high-grade dysplasia peaked around 31 to 40 years, and squamous cell carcinoma peaked among 51 to 60 years. Madurai ranked high in the incidence of both high-grade dysplasia and carcinoma.

Conclusion

Incidence of dysplasia and carcinoma in our study was comparable to those seen in the literature. Integration of HPV deoxyribonucleic acid studies into the program can increase the detection rate, detect the progressors, help to identify the HPV species prevalent in an area, and aid in formulating cost-effective HPV vaccine cocktail.

How to cite this article

Ibrahim SS, Kesavaraj K, Arun M, Ameen SAM, Sankar R. Review of Cervical Carcinoma Screening Program in Tamil Nadu – Current Trend and Recommendations from a Histopathologist’s Viewpoint. J South Asian Feder Menopause Soc 2017;5(1):1-7.

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  1. National cancer registry programme, twoyear report of the hospital based cancer registries 1999-2000. Bangalore: ICMR; 2005. p. 3.
  2. Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study. Lancet 2002 Mar;359(9312):1085-1092.
  3. Chlamydia trachomatis infection as a risk factor for invasive cervical cancer. Int J Cancer 2000 Jan;85(1):35-39.
  4. Prevalence and distribution of high-risk human papilloma virus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh, India. BMC Infect Dis 2005 Dec;5:116.
  5. Relationships of human papillomavirus type, qualitative viral load, and age with cytologic abnormality. Cancer Res 2006 Oct;66(20):10112-10119.
  6. Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital types. Obstet Gynecol 1992 Mar;79(3):328-337.
  7. Visual Inspection with Acetic Acid (VIA) screening program: 7 years’ experience in early detection of cervical cancer and pre-cancers in rural South India. Indian J Community Med 2015 Jul-Sep;40(3):203-207.
  8. Initial results from a randomized trial of cervical visual screening in rural South India. Int J Cancer 2004 Apr;109(3):461-467.
  9. Visual inspection of cervix with Lugol’s iodine for early detection of premalignant & malignant lesions of cervix. Indian J Med Res 2012 Aug;136(2):265-271.
  10. Genital warts and risk of cancer: a Danish study of nearly 50000 patients with genital warts. J Infect Dis 2012 May;205(10):1544-1553.
  11. Unusual patterns of squamous epithelium of the uterine cervix: cytologic and pathologic study of koilocytic atypia. Ann N Y Acad Sci 1956 Mar;63(6):1245-1261.
  12. Condylomatous lesions of the cervix and vagina. Cytotogical patterns. Acta Cytol 1976 Nov-Dec;20(6):505-509.
  13. Natural history of precancerous and early cancerous lesions of the uterine cervix. Acta Cytol 1987 May-Jun;31(3):226-234.
  14. Premalignant and malignant lesions of cervix. Indian J Med Res 1978;67:97-105.
  15. Prospective follow-up suggests similar risk of subsequent cervical intraepithelial neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsy. Am J Obstet Gynecol 2003 Jun;188(6):1406-1412.
  16. Accuracy of visual screening for cervical neoplasia: results from an IARC multicentre study in India and Africa. Int J Cancer 2004 Jul;110(6):907-913.
  17. Visual inspection with acetic acid and cytology in the early detection of cervical neoplasia in Kolkata, India. Int J Gynecol Cancer 2003 Sept-Oct;13(5):626-632.
  18. , editor. Cervical cancer screening programme 2000. Reducing the risk. NHS Cervical Cancer Screening Programme. Sheffield: National Health Service; 2000: 409-411.
  19. Cervical cancer screening in Australia 1997–1998. AIHW Cat No 9. Canberra: Australian Institute of Health and Welfare; 2000:13-32.
  20. Behaviour of mild cervical dysplasia during long-term follow-up. Obstet Gynecol 1986 May;67(5):665-669.
  21. Behaviour of moderate cervical dysplasia during long-term follow-up. Obstet Gynecol 1983 May;61(5):609-614.
  22. Human papilloma virus ICMR: high power committee to evaluate performance of ICMR, 2012–2013. New Delhi: ICMR; 2014. p. 1-13
  23. Persistence of type specific human papilloma virus infections among cytologically normal women. J Infect Dis 1996 Feb;(174):927-936.
  24. CIN 3: the role of lesion size in invasion. Br J Obstet Gynaecol 1992 Jul;99(7):583-586.
  25. A prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2, based on simple clinical parameters. Available from: http://dx.doi.org/10.1016/j.humpath.2016.09.012.
  26. SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma. Available from: http://dx.doi.org/10.1016/j.humpath.2016.09.019.
  27. Stage IB adenocarcinoma of the cervix treated by radical hysterectomy and pelvic lymph node dissection. Am J Obstet Gynecol 1989 Jun;160(6):1509-1514.
  28. Cost-effectiveness of cervical cancer screening in five developing countries. N Engl J Med 2005;353:2158-2168.
  29. The interpretive variability of cervical biopsies and its relationship to HPV status. Am J Surg Pathol 2015 Jun;39(6):729-736.
  30. A meta-analysis of human papillomavirus type-distribution in women from South Asia: implications for vaccination. Vaccine 2008 Jun;26(23):2811-2817.
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