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VOLUME 5 , ISSUE 2 ( July-December, 2017 ) > List of Articles


Effect of Menopause on Pulmonary Functions: An Analysis!

Kshama V Kedar, Radha P Munje, Amar K Karia

Citation Information : Kedar KV, Munje RP, Karia AK. Effect of Menopause on Pulmonary Functions: An Analysis!. J South Asian Feder Menopause Soc 2017; 5 (2):99-101.

DOI: 10.5005/jp-journals-10032-1115

License: CC BY 3.0

Published Online: 01-07-2011

Copyright Statement:  Copyright © 2017; The Author(s).



Sex hormones play an important role in women's health. There is a close relationship between female sex hormones and lung function in postmenopausal women. Deterioration of lung function is observed more after menopause. Estrogen deficiency after menopause accelerates the adverse effects of biological aging on lung mechanics in postmenopausal women. Our study uses a spirometer to analyze and evaluate these effects of menopausal aging.


To study the effects of menopause on pulmonary function tests in women of perimenopausal age group.

Materials and methods

This study was carried out in the Department of Obstetrics and Gynecology in Indira Gandhi Government Medical College & Hospital (IGGMC) Nagpur, India. Totally 50 women each in premenopausal and menopausal age groups were included in our study. Venous blood was collected under aseptic precautions on 10 to 14 and 18 to 23 days corresponding to follicular and luteal phase of menstrual cycle in premenopausal and postmenopausal women. Serum estrogen and progesterone levels were estimated by microparticle enzyme immunoassay. The pulmonary function of all subjects was measured with digital microspirometer and data collected. The peak expiratory flow rate (PEFR), forced expiratory flow (FEF)25-75, forced expiratory volume (FEV1), and forced vital capacity (FVC) were studied and correlated with symptoms. Data analysis was done using Student's unpaired t-test and chi-squared test.


The mean percentages of predicted values of FEF25-75 and PEFR were lower in postmenopausal women compared with premenopausal women. Mean serum estrogen levels were significantly lower in postmenopausal women as compared with premenopausal women. Progesterone levels were lower in postmenopausal women and in proliferative phase of premenopausal women as compared with luteal phase of menstrual cycle.


As menopause sets in, decrease in hormonal levels leads to decreased lung capacity as evident by pulmonary function tests. Decreased pulmonary function test can be attributed to lower levels of sex hormones estrogen and progesterone in postmenopausal women.

How to cite this article

Karia AK, Kedar KV, Munje RP. Effect of Menopause on Pulmonary Functions: An Analysis! J South Asian Feder Menopause Soc 2017;5(2):99-101.

  1. The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies. Am J Physiol Lung Cell Mol Physiol 2007 Aug;293(2):272-278.
  2. Heart spring. Concho (AZ): Heartspring; 20007. [cited 2007 Jun 4]. Available from: .
  3. Review of medical physiology 22nd edn. New York: McGraw-Hill; 2005.
  4. Effect of aging on respiratory system physiology and immunology. Clin Interv Aging 2006 Sep;1(3): 253-260.
  5. Toward therapeutic pulmonary alveolar regeneration in humans. Proc Am Thorac Soc 2006 Nov;3(8):709-712.
  6. Postmenopausal hormone replacement therapy. N Engl J Med 2001 Jul;345(1):34-40.
  7. Asthma and sex hormones. Allergy 2001 Jan;56(1):13-20.
  8. The effect of hormone replacement therapy type on pulmonary functions in postmenopausal women. Maturitas 2003 Nov;46(3):213-218.
  9. The effects of hormone therapy on pulmonary function tests in postmenopausal women. Maturitas 2004 Nov;49(3):221-227.
  10. The effects of hormone replacement therapy and pulmonary functions in postmenopausal women. Tuberk Toraks 2004;52(3):237-242.
  11. Correlative study IOB blood pressure and lung function profiles during different phases of menstrual cycle among Indian population. Thai J Physiol Sci 2004 Aug;17(2):30-34.
  12. Effects of steroid on beta-adrenoceptor-mediated relaxation of pig bronchus. Br J Pharmacol 1983 Feb;78(2):441-445.
  13. Upper airway muscle activity in normal woman: influence of hormonal status. J Appl Physiol (1985) 1998 Mar;84(3):1055-1062.
  14. An estrogen-stimulated, progesterone-binding system in the hamster uterus and vagina. Steroids 1972 Feb;19(2):263-274.
  15. Estrogen action on bone mass of postmenopausal women is dependent on body mass and initial bone density. J Clin Endocrinol Metab 1995 Mar;80(3):776-782.
  16. Long-term prevention of postmenopausal osteoporosis by estrogen. Evidence for an increased bone mass after delayed onset of estrogen treatment. Lancet 1976 May;1(7968):1038-1041.
  17. Cardiac autonomic dysfunction in obese subjects. Clin Sci (Lond) 1989 Jun;76(6):567-572.
  18. Effects of estrogen on skeletal myoblast growth. Biochem Biophys Res Commun 1997 Mar;232(2):373-378.
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