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VOLUME 6 , ISSUE 1 ( January-June, 2018 ) > List of Articles

Guest Editorial

Emergence of Metabolic Syndrome Out of Menopausal Box!!!

Gangadhar Sahoo

Keywords : Cardiovascular disease, Menopause, Metabolic syndrome, Prevention, Risk factors

Citation Information : Sahoo G. Emergence of Metabolic Syndrome Out of Menopausal Box!!!. J South Asian Feder Menopause Soc 2018; 6 (1):1-7.

DOI: 10.5005/jp-journals-10032-1125

Published Online: 01-06-2017

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Metabolic syndrome is the constellation of risk factors that predisposes to increased risk of cardiovascular diseases (CVD) and type 2 diabetes mellitus that is increasingly coming to light in menopausal females, thereby raising the morbidity and mortality. Declining estrogen levels along with genetic susceptibility and central obesity adversely affect the lipid metabolism, making postmenopausal females vulnerable to metabolic syndrome. Early identification of the various risk factors and appropriate preventive strategies (lifestyle modification and use of statins in selective cases) may decrease the emergence of metabolic syndrome in such females, thereby improving the longevity. Screening of risk factors for metabolic syndrome in postmenopausal females should be routinely done and therefore incorporated and inculcated in every postmenopausal clinic so that suitable candidates can be referred to cardiologists for expert advice and proper intervention if required.


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  1. Ahuja M. Age of menopause and determinants of menopause age: a PAN India survey by IMS. J Midlife Health 2016 Jul- Sep;7(3):126-131.
  2. Bastian LA, Smith CM, Nanda K. Is this woman perimenopausal? JAMA 2003 Feb;289(7):895-902.
  3. Santoro N, Brockwell S, Johnston J, Crawford SL, Gold EB, Harlow SD, Matthews KA, Sutton-Tyrrell K. Helping midlife women predict the onset of the final menses: SWAN, the Study of Women's Health Across the Nation. Menopause 2007 May- Jun;14(3 Pt 1):415-424.
  4. Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ; STRAW + 10 Collaborative Group. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of
  5. J Clin Endocrinol Metab 2012 Apr;97(4):1159-1168.
  6. Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ; STRAW + 10 Collaborative Group. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. Menopause 2012 Apr;19(4):387-395.
  7. Freeman EW, Sammel MD, Lin H, Gracia CR, Pien GW, Nelson DB, Sheng L. Symptoms associated with menopausal transition and reproductive hormones in midlife women. Obstet Gynecol 2007 Aug;110(2 Pt 1):230-240.
  8. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, et al; American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005 Oct;112(17):2735-2752.
  9. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C; American Heart Association; National Heart, Lung, and Blood Institute. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004 Jan;109(3):433-438.
  10. Fowler MJ. Microvascular and macrovascular complications of diabetes. Clin Diabetes 2008 Apr;26(2):77-82.
  11. CDC. NHANES III. Atlanta (GA): CDC; 2009. [cited 2013 Aug 30]. Available from: www.cdc.gov/nchs/nhanes/nh3data. htm.
  12. Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 2002 Jun;32(Suppl 3):14-23.
  13. Tooke JE, Hannemann MM. Adverse endothelial function and the insulin resistance syndrome. J Intern Med 2000 Apr;247(4):425-431.
  14. Rochlani Y, Pothineni NV, Kovelamudi S, Mehta JL. Metabolic Syndrome: pathophysiology, management and modulation by natural compounds. Ther Adv Cardiovasc Dis 2017 Aug;11(8):215-225.
  15. Lindsay RS, Funahashi T, Hanson RL, Matsuzawa Y, Tanaka S, Tataranni PA, Knowler WC, Krakoff J. Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 2002 Jul;360(9326):57-58.
  16. Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H, Kumada M, Ohashi K, Okamoto Y, Nishizawa H, et al. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 2003 Sep;42(3):231-234.
  17. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 2004 Apr;291(14):1730-1737.
  18. Hidalgo LA, Chedraui PA, Morocho N, Alvarado M, Chavez D, Huc A. The metabolic syndrome among postmenopausal women in Ecuador. Gynecol Endocrinol 2006 Aug;22(8): 447-454.
  19. Piché ME, Weisnagel SJ, Corneau L, Nadeau A, Bergeron J, Lemieux S. The WHO and NCEP/ATPIII definitions of the metabolic syndrome in postmenopausal women: are they so different? Metab Syndr Relat Disord 2006 Mar;4(1): 17-27.
  20. Kim HM, Park J, Ryu SY, Kim J. The effect of menopause on the metabolic syndrome among Korean women: the Korean National Health an Nutrition Examination Survey, 2001. Diabetes Care 2007 Mar;30(3):701-706.
  21. Ainy E, Mirmiran P, Zahedi Asl S, Azizi F. Prevalence of metabolic syndrome during menopausal transition Tehranian women: Tehran Lipid and Glucose Study (TLGS). Maturitas 2007 Oct;58(2):150-155.
  22. Deibert P, König D, Vitolins MZ, Landmann U, Frey I, Zahradnik HP, Berg A. Effect of a weight loss intervention on anthropometric measures and metabolic risk factors in preversus postmenopausal women. Nutr J 2007 Oct;6:31.
  23. Eshtiaghi R, Esteghamati A, Nakhjavani M. Menopause is an independent predictor of metabolic syndrome in Iranian women. Maturitas 2010 Mar;65(3):262-266.
  24. Figueredo Neto JA, Figuerêdo ED, Barbosa JB, Barbosa Fde F, Costa GR, Nina VJ, Nina RV. Metabolic syndrome and menopause: cross-sectional study in gynecology clinc. Arq Bras Cardiol 2010 Sep;95(3):339-345.
  25. Indavivandhana S, Rattanachaiyanont M, Wongvananurak T, Kanbopn M, Techatraisak K, Leerasiri P, Tanmahasamut P, Angsuwathana S. Predictors for metabolic syndrome in premenopausal and postmenopausal Thai women. Climacteric 2010 Feb;14(1):58-65.
  26. Heidari R, Sadeghi M, Talaei M, Rabiei K, Mohammadifard N, Sarrafzadegan N. Metabolic syndrome in menopausal transition: Isfahan Healthy Heart Program, a population based study. Diabetol Metab Syndr 2010 Oct;2:59.
  27. Ruan X, Jin J, Hua L, Liu Y, Wang J, Liu S. The prevalence of metabolic syndrome in Chinese postmenopausal women and the optimum body composition indices to predict it. Menopause 2010 May-Jun;17(3):566-570.
  28. Tandon VR, Mahajan A, Sharma S, Sharma A. Prevalence of cardiovascular risk factors in postmenopausal women: a rural study. J Midlife Health 2010 Jan;1(1):26-29.
  29. Despres JP, Pouliot MC, Moorjani S, Nadeau A, Tremblay A, Lupien PJ, Theriault G, Bouchard C. Loss of abdominal fat and metabolic response to exercise training in obese women. Am J Physiol 1991 Aug;261(2 Pt 1):E159-E167.
  30. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 2001 May;285(19):2486-2497.
  31. Gohlke-Barwolf C. Coronary artery disease: is menopause a risk factor? Basic Res Cardiol 2000;95(Suppl 1):I77-I83.
  32. Davis SR, Castelo-Branco C, Chedraui P, Lumsden MA, Nappi RE, Shah D, Villaseca P; Writing Group of the International Menopause Society for World Menopause Day 2012. Understanding weight gain at menopause. Climacteric 2012 Oct;15(5):419-429.
  33. Poehlman ET, Toth MJ, Gardner AW. Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann Intern Med 1995 Nov;123(9): 673-675.
  34. Razay G, Heaton KW, Bolton CH. Coronary heart disease risk factors in relation to the menopause. Q J Med 1992 Nov- Dec;85(307-308):889-896.
  35. Larsson B, Bengtsson C, Bjorntorp P, Lapidus L, Sjostrom L, Svardsudd K, Tibblin G, Wedel H, Welin L, Wilhelmsen L. Is abdominal body fat distribution a major explanation for the
  36. Am J Epidemiol 1992 Feb;135(3):266-273.
  37. Meeta, Digumarti L, Agarwal N, Vaze N, Shah R, Malik S. Clinical practice guidelines on menopause: an executive summary and recommendations. J Midlife Health 2013 Apr- Jun;4(2):77-106.
  38. The Writing Group on behalf of the Workshop Consensus Group. Aging, menopause, cardiovascular disease and HRT. International Menopause Society Consensus Statement. Climacteric 2009 Oct;12(5):368-377.
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