Journal of SAFOMS

Register      Login

VOLUME 6 , ISSUE 2 ( July-December, 2018 ) > List of Articles

CASE REPORT

A Rare Case of Endometrial Adenocarcinoma with Renal Clear Cell Carcinoma

Prashanthi Damodharan, Priyanka Mehta, S Gouthaman, K Sriram

Keywords : Endometrial adenocarcinoma, Leptin, Peroxisome proliferators activators receptor gamma, Renal clear cell carcinoma

Citation Information : Damodharan P, Mehta P, Gouthaman S, Sriram K. A Rare Case of Endometrial Adenocarcinoma with Renal Clear Cell Carcinoma. J South Asian Feder Menopause Soc 2018; 6 (2):135-138.

DOI: 10.5005/jp-journals-10032-1158

License: CC BY-NC 4.0

Published Online: 01-06-2019

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Patients diagnosed with cancer have a lifetime risk of developing another de novo malignancy. The incidence of two primaries in the same patient is an extremely rare condition, and there are no specific guidelines for management. There are less than ten reported cases of coincidental renal cell cancer in a patient with endometrial cancer. In a woman who presented with postmenopausal bleeding with endometrial carcinoma, an incidental primary renal cell carcinoma was diagnosed and treated successfully by a multidisciplinary team of gynecologists, oncosurgeon, urologist, radiologist, pathologist, and a medical oncologist. We are reporting this case due to its rarity and clinical interest. A high index of clinical suspicion would go a long way in the management of such tumors.


PDF Share
  1. Warren S, Gates O. Multiple primary malignant tumors: A survey of the literature and a statistical study. Am J Cancer 1932;16:1358-1414.
  2. Kim JW, Han JW, et al. Synchronous double primary malignant tumor of the gallbladder and liver: a case report. World J Surg Oncol 2011;9:84.
  3. Moertel CG. Multiple primary malignant neoplasms: historical perspectives. Cancer 1977;40(4 Suppl):1786-1792. PMID No 332330
  4. Di Silverio F, Sciarra A, et al. Multiple primary tumors: 17 cases of renal-cell carcinoma associated with primary tumors involving different steroid hormone target tissues. World J Urol 1997;15(3):203-209. PMID 9228728.
  5. Bhat HK, Hacker HJ, et al. Localization of estrogen receptors in interstitial cells of hamster kidney and in estradiol-induced renal tumors as evidence of the mesenchymal origin of this neoplasm. Cancer Res 1993;53(22):5447-5451.
  6. Cymbaluk A, Chudecka-Glaz A, et al. Leptin levels in serum depending on Body Mass Index in patients with endometrial hyperplasia and cancer. Eur J Obstet Gynecol Reprod Biol 2008 Jan;136(1):74-77.
  7. Wang PP, He XY, et al. High leptin level is an independent risk factor of endometrial cancer: a meta-analysis. Cell Physiol Biochem. 2014;34(5):1477-84. Epub 2014 Oct 8. PMID:25322729
  8. Zhou X, Li H, et al. Leptin Inhibits the Apoptosis of Endometrial Carcinoma Cells Through Activation of the Nuclear Factor κB-inducing Kinase/IκB Kinase Pathway. Int J Gynecol Cancer. 2015 Jun;25(5):770-778. PMID: 25811593
  9. Smith WM, Zhou XP, et al. Opposite association of two PPARG variants with cancer: overrepresentation of H449H in endometrial carcinoma cases and underrepresentation of P12A in renal cell carcinoma cases. Hum Genet 2001;109(2):146-51.PMID 11511919
  10. Suzuki S, Nishimaki T, et al. Outcomes of simultaneous resection of synchronous esophageal and extra esophageal carcinomas. J Am Coll Surg 2002;195(1):23-29. PMID 12113541.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.