Journal of SAFOMS

Register      Login

VOLUME 8 , ISSUE 1 ( January-June, 2020 ) > List of Articles

Original Article

Evaluation of Thyroid Hormone Profile in Abnormal Uterine Bleeding

Mini Bedi, Simrat K Khosa, Ishita Das, Harkiran K Khaira, Kapil Gupta

Keywords : Abnormal uterine bleeding, Hyperthyroid, Hypothyroid, Menstrual patterns, Thyroid hormone

Citation Information : Bedi M, Khosa SK, Das I, Khaira HK, Gupta K. Evaluation of Thyroid Hormone Profile in Abnormal Uterine Bleeding. J South Asian Feder Menopause Soc 2020; 8 (1):37-41.

DOI: 10.5005/jp-journals-10032-1205

License: CC BY-NC 4.0

Published Online: 18-00-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: Making up 20–30% of cases in the outpatient clinic, abnormal uterine bleeding (AUB) is a common diagnosis with considerable social and economic impact. Complaints of heavy menstrual bleeding significantly affect the quality of life resulting in time off work, thus leading to surgical intervention including hysterectomy and ultimately posing a significant impact on the health care system. Timely and appropriate management will prevent most of these problems. Materials and methods: Two hundred and forty-six women with AUB visiting outpatient Department of Obstetrics and Gynecology, AIMSR, Bathinda were included in the study after informed written consent. History and examination, ultrasonography, and serum thyroid-stimulating hormone (TSH) levels were done for all patients. The prevalence of thyroid hormone dysfunction in AUB was evaluated and the association between various menstrual patterns and thyroid profile was assessed. Results: Out of 116 cases presenting with heavy menstrual bleeding, 79 were hypothyroid, 5 were hyperthyroid, and 32 were euthyroid. Also, out of the 37 cases presenting with light menstrual bleeding, 16 were hypothyroid closely followed by 13 hyperthyroid cases. These results were statistically significant. Moreover, the most common AUB pattern in the hypothyroid group was heavy menstrual bleeding (79 cases out of 117 cases), while in the hyperthyroid group was light menstrual bleeding (in 13 cases out of 22 cases). Conclusion: The key to early diagnosis is to maintain a high index of suspicion and readily screen for the presence of abnormal thyroid function.


PDF Share
  1. Nesse R. Abnormal vaginal bleeding in perimenopausal women. Am Family Physician 1989;40:185.
  2. Ali J, Das KK, Konyak P. Study of relation of thyroid profile with abnormal uterine bleeding. Sch J App Med Sci 2015;3(7D):2688–2692.
  3. Bhardwaj M, Modi J, Agarwal V. Study of thyroid function in dysfunctional uterine bleeding. Nat J Med Dent Res 2015;4(1):6–10.
  4. Harlow SD, Ephross SA. Epidemiology of menstruation and its relation to women's health. Epidemiol Rev 1995;17(2):265–286. DOI: 10.1093/oxfordjournals.epirev.a036193.
  5. Speroff L, Fritz MA. Clinical Gynecologic Endocrinology And Infertility. 7th ed., Philadelphia, PA: Lippincott Williams and Wilkins; 2005. p. 402. 547, 549.
  6. Padmaleela K, Thomas V, Lavanya KM, et al. Thyroid disorders in dysfunctional uterine bleeding (DUB) among reproductive age group women - a cross-sectional study in tertiary care hospital in Andhra Pradesh, India. Int J Med Pharm Sci 2013;(1):41–46.
  7. Sharma N, Sharma A. Thyroid profile in menstrual disorders. JK Science 2012;14(1):14–17.
  8. Bhavani N, Sathineedi A, Giri A, et al. A study of correlation between abnormal uterine bleeding and thyroid dysfunction. Int J Rec Trends Sci Technol 2015;14(1):131–135.
  9. Dass A, Chughs S. Dysfunctional uterine bleeding. J Obstet Gynae India 1964;348–353.
  10. Pawha S, Kaur G. Thyroid dysfunction in dysfunctional uterine bleeding. JARBS 2013;5(1):78–83.
  11. Singh S, Sahoo S, Das PC. A study of thyroid dysfunction in dysfunctional uterine bleeding. Int J Reprod Contracept Obstet Gynecol 2018;7(3):1002–1006. DOI: 10.18203/2320-1770.ijrcog20180881.
  12. Betha K, Malavatu L, Talasani S. Distribution of causes of abnormal uterine bleeding using new FIGO classification system-PALM COEIN: a rural tertiary hospital based study. Int J Reprod Contracept Obstet Gynecol 2017;6(8):3523–3527. DOI: 10.18203/2320-1770.ijrcog20173476.
  13. Choudhary J, Acharya V, Jain M. Evaluation of abnormal uterine bleeding with transvaginalsonography and hysteroscopy in perimenopausal women. Int J Reprod Contracep Obstet Gynecol 2017;6(8):3607–3613. DOI: 10.18203/2320-1770.ijrcog20173494.
  14. Shrestha A, Kayastha B, Makaju R. Diagnostic hysteroscopy in abnormal uterine bleeding: a five years study in Kathmandu University hospital. Int J Sci Rep 2017;3(5):128–133. DOI: 10.18203/issn.2454-2156.IntJSciRep20171998.
  15. Babu PS, Delvadia JL, Desai DA. Clinicopathological and endocrine correlation in cases of menstrual disturbances. Journal of SMt NHL MED Coll, Ahmedabad.
  16. Moghal N. Diagnostic value of endometrial curettage in abnormal uterine bleeding-a histopathological study. J Pak Med Assoc 1997;47(12):295–299.
  17. Pilli GS, Sethi B, Dhaded AV, et al. Dysfunctional uterine bleeding. J Obst Gynae India 2001;52(3):87–89.
  18. Scott JC, Mussey E. Menstrual patterns in myxoedema. Am J Obst Gyn 1964;90(2):161–165. DOI: 10.1016/0002-9378(64)90476-4.
  19. Kaur T, Aseeja V, Sharma S. Thyroid dysfunction in dysfunctional uterine bleeding. Webmed Central Obstet Gynecol 2011;2(9): WMC002235.
  20. Mahapatra M, Mishra P. Clinicopathological evaluation of abnormal uterine bleeding. J Health Res Rev 2015;2:45–49.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.